The Sadhukhan Lab @ IIT Palakkad
Department of Chemistry
Journal Publications
45. Kannan, K.; George, J. A.; Sahadevan, R.; Kothari, M.; Sadhukhan, S.* Insights into one drug, multi-target aspects of polyphenols for diabetes management: In vitro, in vivo, and clinical evidence. Phytochem. Rev., 2024, Just Accepted.
44. Kothari, M.; Kannan, K.; Sahadevan, R.; Retnakumar, S. V.; Chauvin, C.; Bayry, J.; Sadhukhan, S.* Lipophilic derivatives of EGCG as potent α-amylase and α-glucosidase inhibitors ameliorating oxidative stress and inflammation. Bioorg. Chem., 2024, 153, 107786.
43. Chathangad, S. N.; Vijayan, V. N. ; Bovas, N. A. ; Sahadevan, R.; Sadhukhan, S.* Membrane-active amphiphilic EGCG derivatives and their silver nanoparticles-formulation as broad-spectrum antibacterial and antibiofilm agents. ACS Appl. Nano Mater., 2024, 7, 18920–18931 ( Authors contributed equally)
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42. Vijayan, V. N.; Kannan, K.; Sahadevan, R.; Jose, A.; Porel, M.*; Sadhukhan, S.* ε-Poly-L-lysine: A naturally-occurring biodegradable polypeptide for selective detection of 5-nitroimidazole antibiotics in animal products and living cells via fluorescence. ACS Appl. Bio Mater., 2024, 7, 4654.
41. Kothari, M. ; Kannan, K. ; Sahadevan, R.; Sadhukhan, S.* Novel molecular hybrids of EGCG and quinoxaline: Potent multi-targeting antidiabetic agents that inhibit α-glucosidase, α-amylase, and oxidative stress. Int. J. Biol. Macromol., 2024, 263, 130175. ( Both authors contributed equally)
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40. Sahadevan, R.; Kannan, K.; Jose, A.; Porel, M.*; Sadhukhan, S.* Unconventional fluorescence behaviour of ε-polylysine: Selective and sensitive detection of Cu(II) in real water samples, test paper strips, living cells, and anticounterfeiting applications. Sens. Actuators B Chem, 2024, 409, 135589.
39. Binoy, A.; Kothari, M. ; Sahadevan, R. ; Poddar, S.; Kar, P.; Sadhukhan, S.* Protein S-palmitoylation is markedly inhibited by 4"-alkyl ether lipophilic derivatives of EGCG, the major green tea polyphenol: In vitro and in silico studies. Biochim. Biophys. Acta Biomembr., 2024, 1866, 184264. ( Both authors contributed equally)
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38. Jose, A.; Vijayan, V. N.; Sahadevan, R.; Porel, M.*; Sadhukhan, S.* Selective luminescent detection of 5-nitroimidazole antibiotics through self-aggregates of a single non-aromatic amino acid, L-lysine. Microchem. J., 2024, 197, 109802.
37. Vignesh, A.; Binoy, A.; Thurakkal, L.; Bhuvanesh, N.S.P.; Sadhukhan, S.*; Porel, M.* Pyrene aroylhydrazone-based Pd(II) complexes for DNA/protein binding, cellular imaging and in vitro anticancer activity via ROS production. J. Mol. Struct., 2024, 1295, 136693.
36. Chaturvedi, S.; Pandya, N.; Sadhukhan, S.; Sonawane, A.* Identification of selective plant-derived natural carotenoid and flavonoids as the potential inhibitors of DHHC-mediated protein S-palmitoylation: An in-silico study. J Biomol. Struct. Dyn. in press. 2024.
35. Singh, S.; Ghosh, P.; Roy, R.; Behera, A.; Sahadevan, R.; Kar, P.; Sadhukhan, S.*; Sonawane, A.* 4"-Alkyl EGCG derivatives induce cytoprotective autophagy response by inhibiting EGFR in glioblastoma cells. ACS Omega, 2024, 9, 2286–2301.
34. Sahadevan, R. ; Binoy, A. ; Shajan, I.; Sadhukhan, S.* Mitochondria-targeting EGCG derivatives protect H9c2 cardiomyocytes from H2O2-induced apoptosis: Design, synthesis and biological evaluation. RSC Adv., 2023, 13, 29477-29488. ( Both authors contributed equally)
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33. Singh, S.; Sadhukhan, S.*; Sonawane, A.* 20 years since the approval of first EGFR-TKIs, Gefitinib: Insight and foresight. Biochim. Biophys. Acta: Rev. Cancer., 2023, 1878, 188967.
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32. Sahadevan, R.#; Jose, A.#; Porel, M.*; Sadhukhan, S.* Non-aromatic single amino acid, lysine: A simple fluorescence sensor for selective detection of Cu (II) and Co(II) with colorimetric distinction by the virtue of its self-aggregation behaviour. J. Photochem. Photobiol. A Chem., 2023, 445, 115086. (# Both authors contributed equally)
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31. Chaturvedi, S.; Biswas, M.; Sadhukhan, S.*; Sonawane, A.* Role of EGFR and FASN in breast cancer progression. J. Cell. Commun. Signal., 2023, 17, 1249–1282.
30. Jose, A.; Chathangad, S. N.; Sahadevan, R.; Binoy, A.; Vignesh, A.; Sadhukhan, S.*; Porel, M.* Design, synthesis, and applications of pyrene-quinoline based cell-permeable AIEgen for cellular imaging and antibacterial activity. J. Photochem. Photobiol. A Chem., 2023, 444, 114950.
29. Sahadevan, R.; Binoy, A.; Vechalapu, S.K.; Nanjan, P.; Sadhukhan, S.* In situ global proteomics profiling of EGCG targets using a cell-permeable and Click-able bioorthogonal probe. Int. J. Biol. Macromol., 2023, 237, 123991.
28. Jose, A.#; Sahadevan, R.#; Vijay, M.; Sadhukhan, S.*; Porel, M.* Dansyl-appended sequence-defined oligomers for selective ultrasensitive detection of Hg2+ in water, paper strips, living cells and its efficient removal. Sens. Actuators B Chem., 2023, 380, 133335. (# Both authors contributed equally)
27. Sahadevan, R.; Singh, S.; Binoy, A.; Sadhukhan S*. Chemico-biological aspects of (−)-epigallocatechin-3-gallate (EGCG) to improve its stability, bioavailability and membrane permeability: Current status and future prospects. Crit. Rev. Food. Nutr. Sci., 2023, 63, 10382-10411.
26. Singh, S.; Sahadevan, R.; Roy, R.; Biswas, M.; Ghosh, P.; Kar, P.; Sonawane, A.; Sadhukhan, S.* Structure-based design and synthesis of a novel long-chain 4′′-alkyl ether derivative of EGCG as potent EGFR inhibitor: In vitro and in silico studies. RSC Adv., 2022, 12, 17821-17836.
25. Singh, S.; Sk M.F.; Sonawane, A.; Kar, P.; Sadhukhan, S.* Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA-dependent RNA polymerase (RdRp) inhibition: An in-silico analysis. J Biomol. Struct. Dyn., 2021, 39, 6249-6264.
24. Abril YLN, Fernandez IR, Hong JY, Chiang YL, Kutateladze DA, Zhao Q, Yang M, Hu J, Sadhukhan S, Li B, He B, Remick B, Bai JJ, Mullmann J, Wang F, Maymi V, Dhawan R, Auwerx J, Southard T, Cerione RA, Lin H, Weiss RS. Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer. Oncogene, 2021, 40, 1644-1658.
23. Thurakkal L#, Singh S#, Roy R, Kar P, Sadhukhan S*, Porel M*. An in-silico study on selected organosulfur compounds as potential drugs for SARS-CoV-2 infection via binding multiple drug targets. Chem. Phys. Lett., 2021, 763, 138193. (# Both authors contributed equally)
22. De I, Sadhukhan S*. Emerging roles of DHHC-mediated protein S-palmitoylation in physiological and pathophysiological context. Euro. J. Cell Biol., 2018, 97, 319-338. Featured on the journal cover page
21. Spiegelman NA, Price IR, Jing H, Wang M, Yang M, Cao J, Hong JY, Zhang X, Aramsangtienchai P, Sadhukhan S, Lin H. Direct comparison of SIRT2 inhibitors: Potency, specificity, activity-dependent inhibition, and on-target anticancer activities. ChemMedChem. 2018, 13, 1890-1894.
20. Tong Z, Wang M, Wang Y, Kim DD, Grenier JK, Cao J, Sadhukhan S, Hao Q, Lin H. SIRT7 is an RNA-activated protein lysine deacylase. ACS Chem. Biol. 2017, 12, 300-310.
19. Sadhukhan S, Liu X, Ryu D, Nelson OD, Stupinski JA, Li Z, Chen W, Zhang S, Weiss RS, Locasale JW, Auwerx J, Lin H. Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Proc. Natl. Acad. Sci. U S A. 2016, 113, 4320-4325. (Highlighted on eight science news outlets including Science Daily, EurekAlert!, Medical News Today)
18. Tong Z, Wang Y, Zhang X, Kim DD, Sadhukhan S, Hao Q, Lin H. SIRT7 is activated by DNA and deacetylates histone H3 in the chromatin context. ACS Chem. Biol. 2016, 11, 742-747.
17. Liu X, Sadhukhan S, Sun S, Wagner GR, Hirschey MD, Qi L, Lin H, Locasale JW. High resolution metabolomics with acyl-CoA profiling reveals widespread remodeling in response to diet. Mol. Cell. Proteomics 2015, 14, 1489-1500.
16. Jin Z, Berthiaume JM, Li Q, Henry F, Huang Z, Sadhukhan S, Gao P, Tochtrop GP, Puchowicz MA, Zhang G-F. Catabolism of 4-hydroxy-2-(E)-nonenal via omega- and omega-1 oxidation: Stimulated by ketogenic diet. J. Biol. Chem. 2014, 289, 32327-32338.
15. Sadhukhan S, Zhang G-F, Tochtrop GP. Modular isotopomer synthesis of γ-hydroxybutyric acid for a quantitative analysis of metabolic fates. ACS Chem. Biol. 2014, 9, 1706-1711.
14. Sadhukhan S, Han Y, Jin Z, Tochtrop GP, Zhang G-F. Glutathionylated 4-hydroxy-2-(E)-alkenal enantiomers in rat organs and its contributions towards the disposal of 4-hydroxy-2-(E)-nonenal in rat liver. Free Rad. Biol. Med. 2014, 70, 78-85.
13. Gatbonton-Schwager TN, Sadhukhan S, Zhang G-F, Letterio JJ, Tochtrop GP. Identification of a negative feedback loop in biological oxidant formation regulated by 4-hydroxy-2-(E)-nonenal. Redox Biol. 2014, 2, 755-763.
12. Yu J, Sadhukhan S, Noriega LG, Moullan N, He B, Weiss RS, Lin H, Schoonjans K, Auwerx J. Metabolic characterization of a Sirt5 deficient mouse model. Sci. Rep. 2013, 3, 2806.
11. Harris SR, Zhang G-F, Sadhukhan S, Wang H, Shi C, Puchowicz MA, Anderson VE, Salomon RG, Tochtrop GP, Brunengraber H. Metabolomics coupled to mass isotopomer analysis as a strategy for pathway discovery: Pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate. Chem. Res. Toxicol. 2013, 26, 213-220.
10. Li Q, Sadhukhan S, Berthiaume JM, Ibarra RA, Tang H, Deng S, Hamilton E, Nagy LE, Tochtrop GP, Zhang G-F. 4-Hydroxy-2-(E)-nonenal (HNE) catabolism and formation of HNE adducts are modulated by β-oxidation of fatty acids in the isolated rat heart. Free Rad. Biol. Med. 2013, 58, 35-44.
9. Zhang G-F, Sadhukhan S, Tochtrop GP, Brunengraber H. Metabolism of gamma-hydroxybutyrate (GHB) in perfused rat livers and hearts. Biochem. J. 2012, 444, 333-341.
8. Harris SR, Zhang G-F, Sadhukhan S, Murphy AM, Tomcik KA, Vazquez EJ, Anderson VE, Tochtrop GP, Brunengraber H. Metabolism of levulinate in perfused rat livers and live rats: Conversion to the drug of abuse 4-hydroxypentanoate. J. Biol. Chem. 2011, 286, 5895-5904.
7. Tomcik KA, Ibarra RA, Sadhukhan S, Han Y, Tochtrop GP, Zhang G-F. Isotopomer Enrichment Assay for Very Short Chain Fatty Acids and Its Metabolic Applications. Anal. Biochem. 2011, 410, 110-117.
6. Zhang G-F, Sadhukhan S, Tochtrop GP, Brunengraber H. Metabolomics, pathway regulation and pathway discovery. J. Biol. Chem. 2011, 286, 23631-23635.
5. Sadhukhan S, Han Y, Zhang G-F, Brunengraber H, Tochtrop GP. Using selective isotopic labeling to quantitate parallel metabolic pathways. J. Am. Chem. Soc. 2010, 132, 6309-6311.
4. Chakrabarti E, Ghosh S, Sadhukhan S, Sayre L, Tochtrop GP, Smith JD. Synthesis and biological evaluation of analogues of a novel inhibitor of beta-amyloid secretion. J. Med. Chem. 2010, 53, 5302-5319.
3. Tochtrop GP, Sadhukhan S, Koner RR, Ghosh S. The syntheses and applications of β-benzylmercaptoethylamine derivatives. Tetrahedron 2009, 65, 10515-10534.
2. Zhang G-F, Kombu RS, Kasumov T, Han Y, Sadhukhan S, Zhang J, Sayre LM, Ray D, Gibson KM, Anderson VE, Tochtrop GP, Brunengraber H. Catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs. J. Biol. Chem. 2009, 284, 33521-33534. (Selected as paper of the week)
1. Majumder AB, Singh B, Dutta D, Sadhukhan S, Gupta MN. Lipase catalyzed synthesis of benzyl acetate in solvent-free medium using vinyl acetate as acyl donor. Bioorg. Med. Chem. Lett. 2006, 16, 4041-4044.
